Isoniazid induced sideroblastic anemia is a rare event.We report case of a 45 year old Caucasian women with development of severe anaemia 4 month after introduction of Isoniazid wella color touch 77 45 as part of Tuberculosis treatment.While haemoglobin fell to 47 g/L and erythrocyte count to 1.
5 G/L, reticulocytes were very low (reticulocyte production index of 0.48), but bone marrow aspirate showed an accelerated erythropoiesis with ringsideroblasts.Anaemia galaxy harmony nc rapidly resolved after cessation of Isoniazid.
We postulate an Isoniazid induced inhibition of the δ-Amino-levulinat-synthase resulting in marked depletion of heam synthesis.